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First vaccine to fully immunize against malaria builds on pandemic-driven RNA tech

September 23, 2021

Gloved hands spread blood from a syringe onto a glass slide, with blood samples in vials visible in the background.
Envato Elements/Studiolucky

The article, “First vaccine to fully immunize against malaria builds on pandemic-driven RNA tech”, written by Monisha Ravisetti, was first published in The Academic Times. Parola Analytics provided technical research for this story.


Consistently ranked as one of the leading causes of death around the world, malaria doesn’t have an effective vaccine yet. But researchers have invented a promising new blueprint for one — with properties akin to the novel RNA-based vaccine for COVID-19.

Making a vaccine for malaria is challenging because its associated parasite, Plasmodium, contains a protein that inhibits production of memory T-cells, which protect against previously encountered pathogens. If the body can’t generate these cells, a vaccine is ineffective. But scientists recently tried a new approach using an RNA-based platform.

Their design circumvented the sneaky protein, allowed the body to produce the needed T-cells and completely immunized against malaria. The patent application for their novel vaccine, which hasn’t yet been tested on humans, was published by the U.S. Patent & Trademark Office on Feb. 4.

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