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Supporting biotech patent strategy with cross-border invalidity research

Supporting a global biotech company to strengthen European patent opposition strategy in complex cell therapy technologies.

The Challenge

Navigating complex biotech prior art search

A global biotechnology company developing cell-based therapies faced a critical need to assess the validity of a European patent during opposition proceedings. The matter required deep technical analysis in a highly specialized area involving human clinical trials, ischemia treatment, angiogenesis, and bone marrow-derived cell therapies.

The internal IP team required a partner capable of navigating complex biomedical literature, clinical trial databases, and global patent filings, while responding quickly to evolving questions from the European Patent Office.

The Solution

A multi-source, iterative invalidity search strategy

We executed a comprehensive invalidity search strategy designed to uncover high-value prior art across jurisdictions and data types.

  • Global patent filings and scientific publications
  • Clinical trial registries and archived company disclosures
  • SEC filings and historical web records
  • Targeted analysis of human trial data predating the effective filing date

Our approach combined deep technical analysis with iterative collaboration, ensuring alignment with the client’s evolving opposition strategy.

We delivered a preliminary report early to facilitate strategic discussion, followed by a detailed final report mapping references against key claim limitations. Throughout the engagement, we collaborated closely with the IP leadership, responding to follow-up questions and refining the search based on procedural developments.

We delivered an end-to-end infringement assessment workflow, combining advanced imaging, material analysis, and claims mapping to provide a clear, evidence-backed view of potential patent alignment.

By integrating structural and compositional analysis with patent claim interpretation, we enabled the client to move from raw device data to actionable insights. This comprehensive approach ensured that every finding directly supported their evidence-of-use evaluation.

Our Impact

Stronger support for patent invalidity arguments

Substantive prior art, detailed technical analysis, and responsive collaboration helped strengthen invalidity arguments and strategic decision-making.

Substantiated obviousness arguments

Delivered prior art directly supporting invalidity positions aligned with opposition strategy.

Enhanced strategic confidence

Provided clear, technically grounded analysis that reinforced decision-making within legal and IP teams.

Responsive, high-quality execution

Enabled the client to adapt quickly to EPO developments through timely deliverables and iterative support.

In need of biotech patent search support?

We work with IP teams to identify, analyze, and assess prior art across multiple technical and non-patent sources, helping inform patent validity and opposition strategies.

Discuss an active matter

The challenge

Assessing European patent validity in a complex biotech domain under evolving opposition timelines.

Why it worked

Integrated, comprehensive search strategy

Combining patent, scientific, and clinical data sources enabled comprehensive and defensible prior art discovery.

The outcome

  • Strong prior art supporting invalidity
  • Improved confidence in opposition strategy
  • Timely, responsive analytical support
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